Lumen/ˈluːmɪn/ Definition 1 of 3Pro Tip 1/3Biological Tubes Refers to interior of tubular structures in the body like veins. The surgeon examined the lumen to make sure there were no blockages. Pro Tip 2/3Not Always Visible Understanding 'lumen' may involve medical images, as it's internal. The X-ray displayed a clear image of the lumen of the esophagus. Pro Tip 3/3Health Indicator A clear lumen can indicate good health; blockages can signal problems. Her healthy arteries had a wide lumen, allowing smooth blood flow.