Midwestern/ˌmɪdˈwestərn/ Definition 1 of 1Pro Tip 1/3Geographic origin Midwestern refers to cultural and geographic aspects from the central part of the U.S. She brought her midwestern hospitality to the bustling city. Pro Tip 2/3Not just location The term can imply values, like friendliness, associated with the Midwest. His midwestern work ethic was evident in his dedication. Pro Tip 3/3Stereotypes Be cautious; 'midwestern' can sometimes stereotype people from this region. Calling that kindness a midwestern trait might be stereotyping.